TOPF Lab

Our goal is to identify cellular mechanisms and 
pharmacological interventions that contribute to
the 
maintenance of protein homeostasis during
human diseases.
 

News

Archive
 

Publications

2024

Analysis of ageing-dependent thiol oxidation reveals early oxidation of proteins involved in core proteostasis functions. 
Jonak K., Suppanz I., Julian B., Chacinska A., Warscheid B., Topf U. 
Life Science Alliance 

doi: 10.26508/lsa.202302300

2023  

Prefoldin 2 contributes to mitochondrial morphology and function. 
Tahmaz I., Shahmoradi Ghahe S., Stasiak M., Liput K.P., Jonak K., Topf U.

BMC Biology

doi: 10.1186/s12915-023-01695-y


Analysis of ageing-dependent thiol oxidation reveals early oxidation of proteins involved in core proteostasis functions. 

Jonak K., Suppanz I., Julian B., Chacinska A., Warscheid B., Topf U. 
BioRxiv

doi: 10.1101/2023.05.08.539783
2022

Prefoldin function in cellular protein homeostasis and human diseases.

Tahmaz I.#, Shahmoradi Ghahe S.#, Topf U.  
Frontiers in Cell and Developmental Biology


doi: 10.3389/fcell.2021.816214 

2021

Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

Sladowska M.#, Turek M.#, Kim M-J, Drabikowski K., Mussulini B.H.M., Mohanraj K., Serwa R.A., Topf U.*, Chacinska A.* 
*Co-correspondence
PLOS Biology 

doi: 10.1371/journal.pbio.3001302
2020

Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.

Gościńska K., Shahmoradi Ghahe S., Domagała S., Topf U. 
Genes 


doi: 10.3390/genes11121432

The evolving role of ribosomes in the regulation of protein synthesis. 
Gościńska K.* and Topf U. 
*Correspondence
Acta Biochimica Polonica


doi: 10.18388/abp.2020_5384
2019

Mitochondrial stress-dependent regulation of cellular protein synthesis.

Topf U.*, Uszczynska-Ratajczak B., Chacinska A.* 
*Co-correspondence
Journal of Cell Science   


doi: 10.1242/jcs.226258

Teneurins ancient function in tissue organization and neuronal guidance in the nematode Caenorhabditis elegans.
Topf U. and Drabikowski K.
Frontiers in Neuroscience 

doi: 10.3389/fnins.2019.00205

before 2019

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.

Topf U.*, Suppanz I.*,  Samluk L., Wrobel L., Böser A., Sakowska P., Knapp B., Pietrzyk M.K. , Chacinska A., Warscheid B. (2018) 
*equal contribution
Nature Communications    

doi: 10.1038/s41467-017-02694-8

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis.
Topf U., Wrobel L., Chacinska A. (2016)  
Trends in Cell Biology   

doi: 10.1016/j.tcb.2016.03.002


Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. 
Wrobel L.*, Topf U.*, Bragoszewski P., Wiese S., Sztolsztener M. E., Oeljeklaus S., Varabyova A., Lirski M., Chroscicki P., Mroczek S., Januszewicz E., Dziembowski A., Koblowska M., Warscheid B. and Chacinska A. (2015)
 *equal contribution
Nature             

doi: 10.1038/nature14951




Research funding

Ongoing projects

2022/47/D/NZ3/01740 (Sonata-18; PI: Katarzyna Jonak)

2022/45/B/NZ1/03714 (Opus-23; PI: Ulrike Topf)

2019/34/E/NZ1/00367 (Sonata Bis-9 Ulrike Topf) 

Completed projects

2022/06/X/NZ1/00757 (Miniatura-6; PI: Kamila Liput) 

DEC-MG-05-22-03 (IBB internal grant to Kamila Liput)

2018/31/B/NZ1/02401 (Opus-16; PI: Ulrike Topf)

2015/19/B/NZ1/03444 (Opus-10; PI: Ulrike Topf)

DEC-MG-4/22-03 (IBB internal grant to Katarzyna Jonak)