Our goal is to identify cellular mechanisms and 
pharmacological interventions that contribute to
maintenance of protein homeostasis during
human diseases.




Prefoldin function in cellular protein homeostasis and human diseases.

Tahmaz I.#, Shahmoradi Ghahe S.#, Topf U.  
Frontiers in Cell and Developmental Biology

doi: 10.3389/fcell.2021.816214 


Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

Sladowska M.#, Turek M.#, Kim M-J, Drabikowski K., Mussulini B.H.M., Mohanraj K., Serwa R.A., Topf U.*, Chacinska A.* 
PLOS Biology 

doi: 10.1371/journal.pbio.3001302

Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.

Gościńska K., Shahmoradi Ghahe S., Domagała S., Topf U. 

doi: 10.3390/genes11121432

The evolving role of ribosomes in the regulation of protein synthesis. 
Gościńska K.* and Topf U. 
Acta Biochimica Polonica

doi: 10.18388/abp.2020_5384

Mitochondrial stress-dependent regulation of cellular protein synthesis.

Topf U.*, Uszczynska-Ratajczak B., Chacinska A.* 
Journal of Cell Science   

doi: 10.1242/jcs.226258

Teneurins ancient function in tissue organization and neuronal guidance in the nematode Caenorhabditis elegans.
Topf U. and Drabikowski K.
Frontiers in Neuroscience 

doi: 10.3389/fnins.2019.00205

before 2019

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.

Topf U.*, Suppanz I.*,  Samluk L., Wrobel L., Böser A., Sakowska P., Knapp B., Pietrzyk M.K. , Chacinska A., Warscheid B. (2018) 
*equal contribution
Nature Communications    

doi: 10.1038/s41467-017-02694-8

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis.
Topf U., Wrobel L., Chacinska A. (2016)  
Trends in Cell Biology   

doi: 10.1016/j.tcb.2016.03.002

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. 
Wrobel L.*, Topf U.*, Bragoszewski P., Wiese S., Sztolsztener M. E., Oeljeklaus S., Varabyova A., Lirski M., Chroscicki P., Mroczek S., Januszewicz E., Dziembowski A., Koblowska M., Warscheid B. and Chacinska A. (2015)
 *equal contribution

doi: 10.1038/nature14951

Our work is supported by