TOPF Lab

Our goal is to identify cellular mechanisms and 
pharmacological interventions that contribute to
the 
maintenance of protein homeostasis during
human diseases.
 

News

Archive
 

Publications

2022

Prefoldin function in cellular protein homeostasis and human diseases.

Tahmaz I.#, Shahmoradi Ghahe S.#, Topf U.  
Frontiers in Cell and Developmental Biology


doi: 10.3389/fcell.2021.816214 

2021

Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

Sladowska M.#, Turek M.#, Kim M-J, Drabikowski K., Mussulini B.H.M., Mohanraj K., Serwa R.A., Topf U.*, Chacinska A.* 
*Co-correspondence
PLOS Biology 

doi: 10.1371/journal.pbio.3001302
2020

Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress.

Gościńska K., Shahmoradi Ghahe S., Domagała S., Topf U. 
Genes 


doi: 10.3390/genes11121432

The evolving role of ribosomes in the regulation of protein synthesis. 
Gościńska K.* and Topf U. 
*Correspondence
Acta Biochimica Polonica


doi: 10.18388/abp.2020_5384
2019

Mitochondrial stress-dependent regulation of cellular protein synthesis.

Topf U.*, Uszczynska-Ratajczak B., Chacinska A.* 
*Co-correspondence
Journal of Cell Science   


doi: 10.1242/jcs.226258

Teneurins ancient function in tissue organization and neuronal guidance in the nematode Caenorhabditis elegans.
Topf U. and Drabikowski K.
Frontiers in Neuroscience 

doi: 10.3389/fnins.2019.00205

before 2019

Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.

Topf U.*, Suppanz I.*,  Samluk L., Wrobel L., Böser A., Sakowska P., Knapp B., Pietrzyk M.K. , Chacinska A., Warscheid B. (2018) 
*equal contribution
Nature Communications    

doi: 10.1038/s41467-017-02694-8

Chatty Mitochondria: Keeping Balance in Cellular Protein Homeostasis.
Topf U., Wrobel L., Chacinska A. (2016)  
Trends in Cell Biology   

doi: 10.1016/j.tcb.2016.03.002


Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. 
Wrobel L.*, Topf U.*, Bragoszewski P., Wiese S., Sztolsztener M. E., Oeljeklaus S., Varabyova A., Lirski M., Chroscicki P., Mroczek S., Januszewicz E., Dziembowski A., Koblowska M., Warscheid B. and Chacinska A. (2015)
 *equal contribution
Nature             

doi: 10.1038/nature14951




Our work is supported by 

2015/19/B/NZ1/03444

2018/31/B/NZ1/02401

2019/34/E/NZ1/00367